Perhaps most concerning are the effects on the scalp itself. Calcium hydroxide's high pH can cause chemical burns that may not be immediately apparent but can damage hair follicles over time. Chronic low-grade inflammation at the scalp level can lead to conditions like
follicular degeneration syndrome (central centrifugal cicatricial alopecia), a form of scarring hair loss more common in women who use chemical relaxers. This condition causes permanent destruction of hair follicles, replacing them with scar tissue and resulting in irreversible hair loss patterns that expand outward from the crown of the head.